Application scenarios of high-precision chillers - Jice (Nanjing) focuses on creating high-precision environments
Release time:
2025-05-21
High-precision chillers are essential because of their ultra-high temperature stability and precise control capabilities in the following scenarios that are extremely sensitive to temperature fluctuations. These scenarios usually involve high-value equipment 、 precision manufacturing processes or cutting-edge scientific research where even slight temperature deviations can lead to product scrap 、 experimental failure or even equipment damage 。
Jicce (Nanjing) Technology Co., Ltd.'s high-precision chiller uses internationally renowned brand compressors, high-quality and high-efficiency copper tube plate heat exchangers, and well-known brand electrical components. Employing self-developed temperature control technology, the outlet water temperature of the chiller can achieve a maximum accuracy of ±0.002℃. This gives the unit high precision, small size, low noise, long life, and easy operation, making it widely used in laboratories, semiconductor chips, electronic component production, precision manufacturing, biomedicine, aerospace, data centers, and other scenarios.
Semiconductor Manufacturing
Core Requirements ±0.001℃~±0.002℃ stability, no vibration interference
Lithography Machine Lens Cooling Lithography machine lenses can cause optical path deviation due to thermal expansion (a 1℃ change may cause 10nm level deformation ), directly affecting the exposure accuracy of 5nm/3nm chips.
For example: ASML EUV lithography machines need to maintain lens temperature fluctuations < ±0.001℃, otherwise
wafer yield will plummet.
wafer yield will plummet.
Etching and Deposition Equipment Chemical Vapor Deposition (CVD) reaction chamber temperature fluctuations > ±0.01℃ will lead to uneven film thickness and chip performance failure.
Technical Solutions ：
Magnetic levitation compressor + plate evaporator (low thermal inertia)
Secondary semiconductor refrigeration compensation
Nitrogen sealed circulating water path (anti-oxidation pollution)
Medical and Life Sciences
Core Requirements ±0.01℃ stability, continuous operation reliability
MRI Superconducting Coil Cooling Superconducting magnets need to maintain -269℃ (liquid helium temperature zone), temperature fluctuations > ±0.005℃ may cause "quench" (superconducting state collapse), leading to millions of equipment downtime.
Case: Siemens 7T MRI needs a high-precision chiller to stabilize the cooling system and avoid quench risks.
Cryo-EM Biological samples are imaged at -180℃, temperature fluctuations > ±0.1℃ will cause ice crystals to destroy the protein structure, affecting resolution (e.g., COVID-19 vaccine development relies on such equipment).
Technical Solutions ：
Dual compressor redundancy + liquid nitrogen pre-cooling
Electromagnetic interference (EMI) design
Oil-free system (avoiding biological contamination)
High-Precision Optics and Lasers
Core Requirements ±0.005℃ stability, coping with transient thermal shock
High-power laser cooling Fiber lasers in pulsed mode may instantly generate 1000W/m² heat flux, temperature fluctuations > ±0.01℃ will cause changes in the beam divergence angle, reducing cutting/welding accuracy.
For example: IPG 20kW laser needs to respond to thermal load within 0.5 seconds, with a temperature control error < ±0.005℃.
Astronomical Telescope Mirror Cooling Large mirrors produce deformation due to temperature gradients (such as the European Extremely Large Telescope E-ELT), and a cooling system is needed to maintain mirror temperature uniformity < ±0.02℃.
Technical Solutions ：
Electronic expansion valve (response time < 0.1 seconds)
Cold storage tank buffers transient loads
Distributed temperature sensor network
New Energy and Materials Research
Core Requirements Precise control at extreme temperatures (e.g., -40℃~150℃)
Lithium battery electrode coating machine cooling Coating oven temperature fluctuations > ±0.1℃ will lead to uneven electrode material thickness, and battery capacity differences > 5%.
Case: A certain company's coating machine requires oven cooling water temperature control of ±0.05℃.
Superconducting Material Testing High-temperature superconducting tapes (such as YBCO) critical current testing needs to maintain temperature fluctuations < ±0.002K at 77K (-196℃), otherwise the test data is invalid.
Technical Solutions ：
Cascade refrigeration system (two-stage compression)
Vacuum insulated piping
Low-temperature antifreeze (such as ethylene glycol/liquid nitrogen mixture)
Quantum computing and scientific research
Core Requirements ：Near absolute zero ultra-low temperature + ultra-stable environment
Dilution refrigerator pre-cooling ：Quantum bits need to be in 10mK (-273.14℃) to operate. High-precision chilled water units are responsible for pre-cooling helium gas to 4K (-269℃). Temperature fluctuations > ±0.001K during the pre-cooling stage will reduce refrigeration efficiency by 50%.
For example: IBM quantum computers require supporting ultra-low temperature chillers.
Gravitational wave detection ：The mirrors of laser interferometers (such as LIGO) need to maintain thermal noise <10^-20 m/√Hz, and the cooling water temperature control needs to reach ±0.001℃.
Technical Solutions ：
Helium gas compression refrigeration + pulse tube refrigeration coupling
Ultra-low vibration design (vibration <1μm/s²)
Radiation shielding layer (isolating environmental thermal radiation)
Food and pharmaceutical industries
Core Requirements ：±0.02℃ stability, compliant with GMP certification
mRNA vaccine lyophilization ：Shelf temperature fluctuations of the freeze dryer > ±0.1℃ will cause damage to the ice crystal structure and inactivation of the active ingredients of the vaccine.
Case: Pfizer's COVID-19 vaccine production requires temperature control of ±0.05℃ during the lyophilization stage.
Precise temperature control of fermenters ：Temperature changes in bioreactors > ±0.2℃ will lead to changes in microbial metabolic pathways (such as insulin production), resulting in a decrease in product purity.
Technical Solutions ：
Hygienic stainless steel evaporator (Ra<0.8μm)
CIP/SIP online cleaning and sterilization function
Data traceability system (compliant with FDA 21 CFR Part 11)
Summary: The irreplaceable nature of high-precision chilled water units
| Scenario | Allowable temperature fluctuation | Consequences of loss of control | Necessary technology |
| Semiconductor lithography | ±0.001℃ | Chip yield <30% | Multi-stage refrigeration + dynamic compensation |
| MRI superconducting coil | ±0.005℃ | Quench loss > 5 million yuan/time | Redundant control + liquid nitrogen backup |
| Quantum computing pre-cooling | ±0.001K | Quantum decoherence time shortened by 90% | Ultra-low temperature + ultra-low vibration |
| Vaccine lyophilization | ±0.05℃ | Entire batch of drugs scrapped (losses exceeding tens of millions of yuan) | GMP certification + aseptic design |
In these scenarios, high-precision chilled water units are not only Temperature control equipment ，but also guarantee Process reliability 、 Product quality and Scientific research breakthroughs Core infrastructure. Its technical value often far exceeds the equipment cost itself—for example, in the semiconductor industry, the downtime loss of a lithography machine can be as high as US$100,000 per minute ，and high-precision chilled water units are the key defense against such risks.
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